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Abstract: This paper presents an approach to modelling the middle phase of HIV infection with medication. The model describes the viral load, concentrations of healthy and infected CD4+ T-cells and CD8+ T-cells in blood. Processes of death, birth, and infection are regarded, as well as infection inhibition and control processes for cell concentrations of the immune system. The main difference between HIV and other infections can be interpreted in terms of the internal coupling structure. The parameters of the model are estimated with the help of clinical data. A method to predict the effect of medication, based on a measurement of initial cell concentrations before therapy begins, is presented.

Note:

Abstract: This paper presents an approach to modelling the middle phase of HIV infection with medication. The model describes the viral load, concentrations of healthy and infected CD4+ T-cells and CD8+ T-cells in blood. Processes of death, birth, and infection are regarded, as well as infection inhibition and control processes for cell concentrations of the immune system. The main difference between HIV and other infections can be interpreted in terms of the internal coupling structure. The parameters of the model are estimated with the help of clinical data. A method to predict the effect of medication, based on a measurement of initial cell concentrations before therapy begins, is presented.