IBI: Research

Actuation and Imaging of Magnetic Nanoparticles

Magnetic Particle Imaging

Actuation and Imaging of Magnetic Nanoparticles

In this project, we exploit the ability of magnetic particle imaging to manipulate magnetic particles with magnetic force and simultaneously image the particles by switching between both modes. In the imaging mode, we perform a normal imaging sequence, while in the force mode, we use the focus fields to move the FFP away from the particles to induce a magnetic force by increasing the magnetic field strength at the particle position. We are able to continuously switch between imaging and force modes and obtain a temporal imaging resolution of 4Hz.

Magnetic force mode

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Members

Florian Griese
Nadine Gdaniec
Tobias Knopp

Publications

[92939]

Title: Imaging and Moving Magnetic Beads with Magnetic Particle Imaging for targeted drug delivery. ISBI 2018

Written by: F. Griese, P. Ludewig, F. Thieben, N. Gdaniec, and T. Knopp

in: 2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018). (2018).

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on pages: 1293-1296

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DOI: 10.1109/ISBI.2018.8363808

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Note: inproceedings, force

Abstract: Magnetic Particle Imaging has proven to resolve superparamagnetic nano-particles within 3D volumes with high sensitivity and with high temporal resolution. Lately, MPI was utilized to track, manipulate and navigate small ferromagnetic devices since the magnetic field topology for imaging is very suitable for generating magnetical forces. In this work, we demonstrate the ability to image and move micro-sized magnetic beads simultaneously with MPI. We are constantly switching between imaging and magnetic force mode to resolve the beads position and manipulate their movement. Beside imaging, the magnetic beads provide a flexible platform for carrying therapeutic substances which can be attached to the bead surface. In combination with force application and imaging this has the potential to provide a tool for automatic drug delivery, e.g. for specific tumor treatment and ischemic stroke dissolution.

Bimodal Fiducial Markers

Magnetic Particle Imaging

Bimodal MRI/MPI Fiducial Markers

In this project we develop bimodal fiducial markers for magnetic resonance and magnetic particle imaging to perform positioning within MPI experiments and to register and fuse images of both modalities.

Compared to most other medical imaging techniques MPI only visualizes an applied tracer without additional morphological information. However, this information is crucial for the interpretation of magnetic particle images and the positioning of objects within the MPI scanner.

Our bimodal fiducial markers provide visual landmarks in MP and MR images. These landmarks can be used as points of reference to perform faithful positioning within the MPI scanner prior to MPI experiments. Furthermore, they can be used for an automated image registration and fusion.

Members

Martin Möddel
Franziska Werner
Caroline Jung, Department of Interventional and Diagnostic Radiology
Rene Werner, Department of Computational Neuroscience
Alexander Schlaefer
Tobias Knopp

Grants

This project was funded by the FMTHH (grant number 01fmthh15)

Publications

[92939]

Title: Imaging and Moving Magnetic Beads with Magnetic Particle Imaging for targeted drug delivery. ISBI 2018

Written by: F. Griese, P. Ludewig, F. Thieben, N. Gdaniec, and T. Knopp

in: 2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018). (2018).

Volume: Number:

on pages: 1293-1296

Chapter:

Editor:

Publisher:

Series:

Address:

Edition:

ISBN:

how published:

Organization:

School:

Institution:

Type:

DOI: 10.1109/ISBI.2018.8363808

URL:

ARXIVID:

PMID:

Note: inproceedings, force

Abstract: Magnetic Particle Imaging has proven to resolve superparamagnetic nano-particles within 3D volumes with high sensitivity and with high temporal resolution. Lately, MPI was utilized to track, manipulate and navigate small ferromagnetic devices since the magnetic field topology for imaging is very suitable for generating magnetical forces. In this work, we demonstrate the ability to image and move micro-sized magnetic beads simultaneously with MPI. We are constantly switching between imaging and magnetic force mode to resolve the beads position and manipulate their movement. Beside imaging, the magnetic beads provide a flexible platform for carrying therapeutic substances which can be attached to the bead surface. In combination with force application and imaging this has the potential to provide a tool for automatic drug delivery, e.g. for specific tumor treatment and ischemic stroke dissolution.

Guidance of Vascular Interventions

Magnetic Particle Imaging

Interventional Magnetic Particle Imaging

Magnetic particle imaging is a new radiation-free tomographic imaging method providing fast, background-free, sensitive, directly quantifiable information about the spatial distribution of SPIOs at high temporal resolution. In this project we investigate its potential to offer an alternative to traditional Digital subtraction angiography in interventional procedures.

Multi-contrast MPI makes it possible to jointly image blood pool tracer and labeled cardiovascular devices.

Members

Publications

[92939]

Title: Imaging and Moving Magnetic Beads with Magnetic Particle Imaging for targeted drug delivery. ISBI 2018

Written by: F. Griese, P. Ludewig, F. Thieben, N. Gdaniec, and T. Knopp

in: 2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018). (2018).

Volume: Number:

on pages: 1293-1296

Chapter:

Editor:

Publisher:

Series:

Address:

Edition:

ISBN:

how published:

Organization:

School:

Institution:

Type:

DOI: 10.1109/ISBI.2018.8363808

URL:

ARXIVID:

PMID:

Note: inproceedings, force

Abstract: Magnetic Particle Imaging has proven to resolve superparamagnetic nano-particles within 3D volumes with high sensitivity and with high temporal resolution. Lately, MPI was utilized to track, manipulate and navigate small ferromagnetic devices since the magnetic field topology for imaging is very suitable for generating magnetical forces. In this work, we demonstrate the ability to image and move micro-sized magnetic beads simultaneously with MPI. We are constantly switching between imaging and magnetic force mode to resolve the beads position and manipulate their movement. Beside imaging, the magnetic beads provide a flexible platform for carrying therapeutic substances which can be attached to the bead surface. In combination with force application and imaging this has the potential to provide a tool for automatic drug delivery, e.g. for specific tumor treatment and ischemic stroke dissolution.

Online Reconstruction

Magnetic Particle Imaging

Online Reconstruction for Magnetic Particle Imaging

MPI is an imaging modality that provides very high acquisition rates with up to 46 volumes per second. However, in practice in order to show images of the SPIO distribution directly on the screen it is equally important that the data reconstruction is fast enough to handle the incoming raw data from the receiver unit. Within this project we develop efficient algorithms that allow to reconstruct the SPIO distribution in near real-time such that the reconstructed images can be shown directly on the acquisition computer.

Members

Publications

[92939]

Title: Imaging and Moving Magnetic Beads with Magnetic Particle Imaging for targeted drug delivery. ISBI 2018

Written by: F. Griese, P. Ludewig, F. Thieben, N. Gdaniec, and T. Knopp

in: 2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018). (2018).

Volume: Number:

on pages: 1293-1296

Chapter:

Editor:

Publisher:

Series:

Address:

Edition:

ISBN:

how published:

Organization:

School:

Institution:

Type:

DOI: 10.1109/ISBI.2018.8363808

URL:

ARXIVID:

PMID:

Note: inproceedings, force

Abstract: Magnetic Particle Imaging has proven to resolve superparamagnetic nano-particles within 3D volumes with high sensitivity and with high temporal resolution. Lately, MPI was utilized to track, manipulate and navigate small ferromagnetic devices since the magnetic field topology for imaging is very suitable for generating magnetical forces. In this work, we demonstrate the ability to image and move micro-sized magnetic beads simultaneously with MPI. We are constantly switching between imaging and magnetic force mode to resolve the beads position and manipulate their movement. Beside imaging, the magnetic beads provide a flexible platform for carrying therapeutic substances which can be attached to the bead surface. In combination with force application and imaging this has the potential to provide a tool for automatic drug delivery, e.g. for specific tumor treatment and ischemic stroke dissolution.

Research Projects

Hardware and Instrumentation

Clinical Surveillance MPI Scanner for Stroke Units

Magnetic Field Characterization

MPI Image Reconstruction

MRI Image Reconstruction

Software

Spectral CT & HR-pQCT

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Completed projects

Actuation and Imaging of Magnetic Nanoparticles

Actuation and Imaging of Magnetic Nanoparticles

Members

Publications