Surveillance MPI Scanner for Stroke Detection on the Intensive Care Stroke Unit

Scientists at the Technical University of Hamburg (TUHH) and the University Hospital Hamburg-Eppendorf (UKE) have developed a new diagnostic tomographic imaging system that enables access to cerebral blood flow at short intervals and thus quickly indicates a possible stroke. The study "Human-sized Magnetic Particle Imaging for Brain Applications" was published on the 26th of April 2019 in the renowned journal Nature Communications.

On the road to full real-time 3D imaging using approved clinical tracers, the MPI scanner has been extensively upgraded from 2019 to 2023. Several publications document the process and highlight the development of new components, like the study "Heat it up: Thermal stabilization by active heating to reduce impedance drifts in capacitive matched networks", "Gradient power reducing using pulsed selection-field sequences" or "Resonant inductive coupling network for human-sized magnetic particle imaging". A thorough exploration is presented in "System characterization of a human-sized 3D real-time magnetic particle imaging scanner for cerebral applications".

Prof. Tobias Knopp and Dr. Matthias Gräser with the surveillance imager

Project Publications

[120374]
Title: First human-sized Magnetic Particle Imaging Device for Cerebral Applications. <em>9th International Workshop on Magnetic Particle Imaging (IWMPI 2019)</em>
Written by: M. Graeser, F. Thieben, P. Szwargulski, F. Werner, N. Gdaniec, M. Boberg, F. Griese, M. Möddel, P. Ludewig, D. van de Ven, O. M. Weber, O. Woywode, B. Gleich, and T. Knopp
in: (2019).
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on pages: 15-16
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Note: inproceedings, brainimager

Abstract: In intensive care units, patients suffering from intracerebral hemorrhage or ischemic stroke cannot be monitored by imaging systems due to the demands of the scanning device like shielded rooms. In this work, we present the first MPI human head scanner, which can operate in unshielded environments. It is compact and flexible and can be integrated further to be a mobile, bedside device. The system demonstrates its capabilities in technical tests as well as on human sized phantoms.