Surveillance MPI Scanner for Stroke Detection on the Intensive Care Stroke Unit

Scientists at the Technical University of Hamburg (TUHH) and the University Hospital Hamburg-Eppendorf (UKE) have developed a new diagnostic tomographic imaging system that enables access to cerebral blood flow at short intervals and thus quickly indicates a possible stroke. The study "Human-sized Magnetic Particle Imaging for Brain Applications" was published on the 26th of April 2019 in the renowned journal Nature Communications.

On the road to full real-time 3D imaging using approved clinical tracers, the MPI scanner has been extensively upgraded from 2019 to 2023. Several publications document the process and highlight the development of new components, like the study "Heat it up: Thermal stabilization by active heating to reduce impedance drifts in capacitive matched networks", "Gradient power reducing using pulsed selection-field sequences" or "Resonant inductive coupling network for human-sized magnetic particle imaging". A thorough exploration is presented in "System characterization of a human-sized 3D real-time magnetic particle imaging scanner for cerebral applications".

Prof. Tobias Knopp and Dr. Matthias Gräser with the surveillance imager

Project Publications

[145074]
Title: Gradient power reducing using pulsed selection-field sequences.
Written by: F. Thieben, M. Boberg, P. Szwargulski, M. Graeser, and T. Knopp
in: <em>International Journal on Magnetic Particle Imaging</em>. (2020).
Volume: <strong>6</strong>. Number: (2),
on pages: 1-3
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DOI: 10.18416/IJMPI.2020.2009054
URL: https://journal.iwmpi.org/index.php/iwmpi/article/view/268
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Note: inproceedings, brainimager

Abstract: Large selection-field power is required to generate a sufficient gradient strength in Magnetic Particle Imaging (MPI). Without cooling, the subsequent heat generation can limit the maximum experiment time. For commercially available MPI scanners a lot of effort was put into active cooling requiring space and infrastructure to dissipate heat. In this abstract, a promising power handling for the selection-field generation is presented. Using a pulsed instead of a continuous selection-field the gradient strength can be increased and no active cooling is required.