Surveillance MPI Scanner for Stroke Detection on the Intensive Care Stroke Unit

Scientists at the Technical University of Hamburg (TUHH) and the University Hospital Hamburg-Eppendorf (UKE) have developed a new diagnostic tomographic imaging system that enables access to cerebral blood flow at short intervals and thus quickly indicates a possible stroke. The study "Human-sized Magnetic Particle Imaging for Brain Applications" was published on the 26th of April 2019 in the renowned journal Nature Communications.

On the road to full real-time 3D imaging using approved clinical tracers, the MPI scanner has been extensively upgraded from 2019 to 2023. Several publications document the process and highlight the development of new components, like the study "Heat it up: Thermal stabilization by active heating to reduce impedance drifts in capacitive matched networks", "Gradient power reducing using pulsed selection-field sequences" or "Resonant inductive coupling network for human-sized magnetic particle imaging". A thorough exploration is presented in "System characterization of a human-sized 3D real-time magnetic particle imaging scanner for cerebral applications".

Prof. Tobias Knopp and Dr. Matthias Gräser with the surveillance imager

Project Publications

[120376]
Title: Determining the Relation between Iron Mass and Spatial Resolution for a Human-Sized Magnetic Particle Brain Imager. <em>9th International Workshop on Magnetic Particle Imaging (IWMPI 2019)</em>
Written by: F. Thieben, M. Graeser, M. Boberg, P. Szwargulski, M. Möddel, and T. Knopp
in: (2019).
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on pages: 41-42
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Note: inproceedings, brainimager

Abstract: The determination of brain perfusion is an important issue for the diagnosis of vascular diseases. Since the total iron dose is limited, the ability to measure and resolve low iron concentrations is of great interest. In this work, we investigated the relation between decreasing iron mass and spatial resolution for a human-sized MPI brain imager. We find the full-width at half maximum of a small delta sample to be a good initial measure for the spatial resolution. In our experiments, the achievable resolution showed only slight decrease over one decade of iron mass.