[BibTex] [pmid]

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Abstract: {BACKGROUND}: Magnetic particle imaging ({MPI}) uses magnetic fields to visualize superparamagnetic iron oxide nanoparticles ({SPIO}). Today, Resovist(®) is still the reference {SPIO} for {MPI}. The objective of this study was to evaluate the in vivo blood half-life of two different types of Resovist (one from Bayer Pharma {AG}, and one from I'rom Pharmaceutical Co Ltd) in {MPI}. {METHODS}: A Resovist concentration of 50 ?mol/kg was injected into the ear artery of ten New Zealand White rabbits. Five animals received Resovist distributed by I'rom Pharmaceutical Co Ltd and five received Resovist by Bayer Pharma {AG}. Blood samples were drawn before and directly after injection of Resovist, at 5, 10, and 15 minutes, and then every 15 minutes until 120 minutes after the injection. The {MPI} signal of the blood samples was evaluated using magnetic particle spectroscopy. {RESULTS}: The average decline of the blood {MPI} signal from the two distributions differed significantly (P=0.0056). Resovist distributed by Bayer Pharma {AG} showed a slower decline of the {MPI} signal (39.7\% after 5 minutes, 20.5\% after 10 minutes, and 12.1\% after 15 minutes) compared with Resovist produced by I'rom Pharmaceutical Co Ltd (20.4\% after 5 minutes, 7.8\% after 10 minutes, no signal above noise level after 15 minutes). {CONCLUSION}: In {MPI}, the blood half-life of an {SPIO} tracer cannot be equalized to the blood half-life of its {MPI} signal. Resovist shows a very rapid decline of blood {MPI} signal and is thus not suitable as a long circulating tracer. For cardiovascular applications in {MPI}, it may be used as a bolus tracer.

[BibTex] [pmid]

Note: article

Abstract: {BACKGROUND}: Magnetic particle imaging ({MPI}) uses magnetic fields to visualize superparamagnetic iron oxide nanoparticles ({SPIO}). Today, Resovist(®) is still the reference {SPIO} for {MPI}. The objective of this study was to evaluate the in vivo blood half-life of two different types of Resovist (one from Bayer Pharma {AG}, and one from I'rom Pharmaceutical Co Ltd) in {MPI}. {METHODS}: A Resovist concentration of 50 ?mol/kg was injected into the ear artery of ten New Zealand White rabbits. Five animals received Resovist distributed by I'rom Pharmaceutical Co Ltd and five received Resovist by Bayer Pharma {AG}. Blood samples were drawn before and directly after injection of Resovist, at 5, 10, and 15 minutes, and then every 15 minutes until 120 minutes after the injection. The {MPI} signal of the blood samples was evaluated using magnetic particle spectroscopy. {RESULTS}: The average decline of the blood {MPI} signal from the two distributions differed significantly (P=0.0056). Resovist distributed by Bayer Pharma {AG} showed a slower decline of the {MPI} signal (39.7\% after 5 minutes, 20.5\% after 10 minutes, and 12.1\% after 15 minutes) compared with Resovist produced by I'rom Pharmaceutical Co Ltd (20.4\% after 5 minutes, 7.8\% after 10 minutes, no signal above noise level after 15 minutes). {CONCLUSION}: In {MPI}, the blood half-life of an {SPIO} tracer cannot be equalized to the blood half-life of its {MPI} signal. Resovist shows a very rapid decline of blood {MPI} signal and is thus not suitable as a long circulating tracer. For cardiovascular applications in {MPI}, it may be used as a bolus tracer.