Dr.-Ing. Matthias Gräser

Universitätsklinikum Hamburg-Eppendorf (UKE)
Sektion für Biomedizinische Bildgebung
Lottestraße 55
2ter Stock, Raum 212
22529 Hamburg

Technische Universität Hamburg (TUHH)
Institut für Biomedizinische Bildgebung
Gebäude E, Raum 4.044
Am Schwarzenberg-Campus 3
21073 Hamburg

Tel.: 040 / 7410 25812
E-Mail: matthias.graeser(at)tuhh.de
E-Mail: ma.graeser(at)uke.de

Research Interests

  • Magnetic Particle Imaging
  • Low Noise Electronics
  • Inductive Sensors
  • Passive Electrical Devices

Curriculum Vitae

Matthias Gräser submitted his Dr.-Ing. thesis in january 2016 at the institute of medical engineering (IMT) at the university of Lübeck and is now working as a Research Scientist at the institute for biomedical imaging (IBI) at the technical university in Hamburg, Germany.  Here he develops concepts for Magnetic-Particle-Imaging (MPI) devices. His main aim is to improve the sensitivity of the imageing devices and improve resolution and application possibilities of MPI technology.

In 2011 Matthias Gräser started to work at the IMT as a Research Associate in the Magnetic Particle Imaging Technology (MAPIT) project. In this project he devolped the analog signal chains for a rabbit sized field free line imager. Additionally he developed a two-dimensional Magnetic-Particle-Spectrometer. This device can apply various field sequences and measure the particle response with a very high signal-to-noise ratio (SNR).

The dynamic behaviour of magnetic nanoparticles is still not fully understood. Matthias Gräser investigated the particle behaviour by modeling the particle behaviour with stochastic differential equations. With this model it is possible to simulate the impact of several particle parameters and field sequences on the particle response .

In 2010 Matthias Gräser finished his diploma at the Karlsruhe Institue of Technology (KIT). His diploma thesis investigated the nerve stimulation of magnetic fields in the range from 4 kHz to 25 kHz.

Journal Publications

Journal Publications

[183658]
Title: Safe and Rapid 3D Imaging: Upgrade of a Human-Sized Brain MPI System.
Written by: F. Thieben, F. Mohn, F. Foerger, N. Hackelberg, J.-P. Scheel, M. Graeser, and T. Knopp
in: <em>International Journal on Magnetic Particle Imaging</em>. mar (2023).
Volume: <strong>9</strong>. Number: (1 Suppl 1),
on pages: 1-4
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DOI: 10.18416/IJMPI.2023.2303045
URL: https://journal.iwmpi.org/index.php/iwmpi/article/view/611
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[www] [BibTex]

Note: inproceedings, brainimager

Abstract: Magnetic Particle Imaging hardware has reached human scale and thus patient safety questions and clinical application scenarios are in the focus of current research. In this work, we present a safe real-time 3D MPI system for cerebral applications. High voltages are avoided to ensure patient safety by a low voltage-high current transmit coil design. The developed 2D drive-field generator generates a field-free-point trajectory in the sagittal xz-plane that is shifted by a dynamic selection-field sequence along the y-axis. The scanner generates 3D images with 4 frames/second and allows for direct visualization of the clinically preferred transversal yz-plane, which is crucial for future brain examinations. Advanced reconstruction techniques reach a system sensitivity of 4 μgFe with respect to the iron mass in a sensitivity study.

Conference Proceedings

Conference Proceedings

[183658]
Title: Safe and Rapid 3D Imaging: Upgrade of a Human-Sized Brain MPI System.
Written by: F. Thieben, F. Mohn, F. Foerger, N. Hackelberg, J.-P. Scheel, M. Graeser, and T. Knopp
in: <em>International Journal on Magnetic Particle Imaging</em>. mar (2023).
Volume: <strong>9</strong>. Number: (1 Suppl 1),
on pages: 1-4
Chapter:
Editor:
Publisher:
Series:
Address:
Edition:
ISBN:
how published:
Organization:
School:
Institution:
Type:
DOI: 10.18416/IJMPI.2023.2303045
URL: https://journal.iwmpi.org/index.php/iwmpi/article/view/611
ARXIVID:
PMID:

[www] [BibTex]

Note: inproceedings, brainimager

Abstract: Magnetic Particle Imaging hardware has reached human scale and thus patient safety questions and clinical application scenarios are in the focus of current research. In this work, we present a safe real-time 3D MPI system for cerebral applications. High voltages are avoided to ensure patient safety by a low voltage-high current transmit coil design. The developed 2D drive-field generator generates a field-free-point trajectory in the sagittal xz-plane that is shifted by a dynamic selection-field sequence along the y-axis. The scanner generates 3D images with 4 frames/second and allows for direct visualization of the clinically preferred transversal yz-plane, which is crucial for future brain examinations. Advanced reconstruction techniques reach a system sensitivity of 4 μgFe with respect to the iron mass in a sensitivity study.