Dr.-Ing. Thomas Wucherpfennig

Boehringer Ingelheim Pharma GmbH & Co. KG
Bioprocess Development Biologicals

Binger Strasse 173

55216 Ingelheim am Rhein

Phone +49 7351 54-144806

Mail Dr. Thomas Wucherpfennig


Thomas pursued the study of Biotechnology at the Technical University of Braunschweig, Germany, and Chemical Engineering at the University of Waterloo, Canada. He earned his PhD in Bioprocess Engineering from the Technical University of Braunschweig. Prior to joining Boehringer Ingelheim as a postdoctoral fellow in 2014, Thomas acquired valuable experience in the industrial biotech sector at Roche and Clariant. Since 2015, he has held various roles in cell culture process development at Boehringer Ingelheim and currently serves as a Senior Principal Scientist, spearheading late-stage process development. In addition, Thomas is a lecturer at FH Oberösterreich in Wels and TUHH – Hamburg University of Technology, His research focus is on bioprocess scale-up, bioreactor characterization, Process Analytical Technology (PAT), and cell culture process modeling.

Research Interests

  • Scale-up of bioprocesses
  • Bioreactor characterization
  • Computational Fluid Dynamics (CFD)
  • Process Analytical Technology (PAT)
  • Cell culture process modelling

Publications

[185007]
Title: Toward in silico CMC: An industrial collaborative approach to model‐based process development.
Written by: D. Roush, D. Asthagiri, D. K. Babi, S. Benner, C. Bilodeau, G. Carta, P. Ernst, M. Fedesco, S. Fitzgibbon, M. Flamm, J. Griesbach, T. Grosskopf, E. B. Hansen, T. Hahn, S. Hunt, F. Insaidoo, A. Lenhoff, J. Lin, H. Marke, B. Marques, E. Papadakis, F. Schlegel, A. Staby, M. Stenvang, L. Sun, P. M. Tessier, R. Todd, E. v. Lieres, J. Welsh, R. Willson, G. Wang, T. Wucherpfennig, O. Zavalov
in: <em>Biotechnol. Bioeng.</em>. (2020).
Volume: <strong>117</strong>. Number: (12),
on pages: 3986-4000
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DOI: https://doi.org/10.1002/bit.27520
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Abstract: The Third Modeling Workshop focusing on bioprocess modeling was held in Kenilworth, NJ in May 2019. A summary of these Workshop proceedings is captured in this manuscript. Modeling is an active area of research within the biotechnology community, and there is a critical need to assess the current state and opportunities for continued investment to realize the full potential of models, including resource and time savings. Beyond individual presentations and topics of novel interest, a substantial portion of the Workshop was devoted toward group discussions of current states and future directions in modeling fields. All scales of modeling, from biophysical models at the molecular level and up through large scale facility and plant modeling, were considered in these discussions and are summarized in the manuscript. Model life cycle management from model development to implementation and sustainment are also considered for different stages of clinical development and commercial production. The manuscript provides a comprehensive overview of bioprocess modeling while suggesting an ideal future state with standardized approaches aligned across the industry.