• Introduction: state-of-the-art and development trends of microbial andbiocatalytic bioprocesses, introduction to the lecture  
• Microbial principles of fermentation, Energetic fundamentals ofbioreaction
• Medium design and optimization, sterilization
• Kinetics of cell growth
• Kinetics of substrate consumption and product formation
• Material balances and metabolic flux analysis
• Transport phenomena in bioreactor and bioprocess scale-u
• Anaerobic fermentation process, integrated downstream processin
• Microaerobic bioprocess: optimal O2 supply, process control and scale-u
• Aerobic process and high cell density culture
• Problem-based learning with selected bioprocesses

The students present exercises and discuss them with their fellow students and faculty statt. In the PBL part of the class the students discuss scientific questions in teams. They acquire knowledge and apply it to unknown questions, present their results and argue their opinions.