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Abstract: The contribution presents a combination of analytical approach and simulation to solve the problem of combined container stowage and ship routing. Based on a real-world use case, the approach is demonstrated, and multiple scenarios are presented to emphasize the different pitfalls and challenges. The presented newly developed mathematical model is used to compute the optimal stowage plan while simultaneously optimizing terminal rotation. The optimal solution is tested for robustness using simulation. The contribution shows that the stowage plan and ship routing are interdependent in a multi-terminal port and a multi-criteria consideration of the departure time, overstows and robustness can be beneficial